Novel Peritoneal Dialysis (PD) Fluid Benefits Chronic Kidney Failure Patients

Highlights:

Alanyl-Glutamine containing peritoneal dialysis fluid receives orphan drug designation in patients suffering from chronic kidney failure.
Reduces the risk of causing a damage to the abdominal tissues resulting in peritoneal membrane failure and peritonitis.
Keeps patients to stay healthy for a long time by relieving the problems that are associated with usual peritoneal dialysis and hemodialysis treatment.

Dialysis - Hemodialysis, Peritoneal Dialysis and Role of Diet and Drugs
Dialysis is an artificial process for removing excess water and waste from the blood. Hemodialysis and peritoneal dialysis are the types of dialysis.

‘Patients who undergo peritoneal dialysis are under the possibility of developing a risk of peritoneal membrane failure and peritonitis. These effects are greatly decreased by using alanyl-glutamine in peritoneal dialysis fluid which extends quality of life.’

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New Peritoneal Dialysis fluid

Alanyl-Glutamine, when added to the peritoneal dialysis fluid, protects the peritoneal tissue by its cytoprotective properties. This new treatment approach prevents the severe complications such as peritoneal membrane failure and peritonitis which are associated with the currently used peritoneal dialysis fluid worldwide.

Zytoprotec, a biopharmaceutical company in Austria discovered the beneficial effects of alanyl-glutamine with the aim to improve the treatment outcomes in patients who are suffering from end-stage kidney disease. The novel peritoneal dialysis fluid that contains alanyl-glutamine has successfully completed a randomized, double-blinded phase II clinical trial. It is currently ready to undergo its crucial phase III clinical trial in nearly about 300 patients suffering from chronic kidney failure both in the United States and Europe.

The United States FDA has granted an orphan drug designation for the new dialysis fluid that contains alanyl-glutamine for treating patients with the end-stage renal disease. This approval will help patients who undergo peritoneal dialysis to stay healthy for longer by avoiding the damage of abdominal tissues. This therapy is considered to be a breakthrough in the treatment of chronic kidney failure which will reduce a huge burden on patients as well as the healthcare system.

Icodextrin Peritoneal Dialysis Solution

This medication is a colloid osmotic agent, used as a dialysis solution for the management of end-stage renal disease.

What is Peritoneal Dialysis?

Peritoneal dialysis is one of the dialysis procedure intended for patients suffering from kidney failure. It involves the introduction of a specific fluid into the lining of the abdomen or peritoneum to filter the blood inside the body. This procedure is employed to correct the electrolyte imbalance and to remove excess fluid and toxins in patients with kidney failure.

The dialysis solution used in peritoneal dialysis is on WHO’s list of essential medicines and considered to be one of the safe and effective medicines needed in a healthcare system. The solution is normally made up of dextrose or icodextrin bicarbonates, minerals, and isotonic solution of sodium chloride.

There are two types of peritoneal dialysis which are

Continuous ambulatory peritoneal dialysis (CAPD)
Automated peritoneal dialysis (APD)

Quiz on Dialysis
Dialysis is a common procedure performed in patients with kidney failure, especially those who are awaiting kidney transplantation. Test your knowledge on dialysis by taking this quiz.

What are the advantages of Peritoneal dialysis?

The advantages of peritoneal dialysis are

Cost-effective
Can be performed at home or at work
Protects residual kidney functions
Involves advanced techniques, exchange systems or new generation of dialysis solutions
Increases quality of life compared with hemodialysis

Chronic Renal Failure - Symptoms, Diagnosis, Complications, Treatment, Prevention
Chronic renal failure or chronic kidney disease is progressive loss in kidney function. The change is irreversible and is due to loss of nephrons of the kidney.

What are the complications of peritoneal dialysis?

The complications of peritoneal dialysis includes

Infection or bleeding in the abdominal area
Elevated blood sugar levels
Blockage of the catheter
Hernia

References:

FDA Grants Orphan Drug Designation to Zytoprotec's Novel Dialysis Fluid - (http://www.checkorphan.org/news/fda-grants-orphan-drug-designation-to-zytoprotecs-novel-dialysis-fluid)
Peritoneal Dialysis - (https://www.niddk.nih.gov/health-information/kidney-disease/kidney-failure/peritoneal-dialysis)
Clinical advantages of peritoneal dialysis - (https://www.ncbi.nlm.nih.gov/pubmed/19270233)

Source-Medindia