To map and track the function of brain circuits affected by autism spectrum disorder (ASD), especially in boys and identify the most effective treatment for an individual, researchers have developed a new method.
The functional biomarker physically measures the progress of patients with behavioural problems -- a tool that has been elusive in autism treatment. "This is significant because biomarkers give us a 'why' for understanding autism in boys that we haven't had before," said one of the researchers Kevin Pelphrey, professor and director of the Autism and Neurodevelopmental Disorders Institute at the George Washington University in the US.
‘Brain imaging is an important intervention tool for autism than the currently used functional MRI.’
The team found that the brain scan data could be an effective indicator of the function of the circuit in younger children and older patients alike. It is particularly relevant for ASD patients who are difficult to diagnose and treat by providing a more definitive diagnosis and in developing a treatment programme when it is not clear if behavioural, drug or a combination of the treatments will be most effective.
"The behavioural symptoms of ASD are so complex and varied it is difficult to determine whether a new treatment is effective, especially within a realistic time frame," said led author Malin Bjornsdotter, assistant professor at the University of Gothenburg in Sweden.
"Brain function markers may provide the specific and objective measures required to bridge this gap," she added in the paper published in the journal JAMA Psychiatry
. In addition, the study also provides evidence that brain imaging is an important intervention tool for autism than the currently used functional MRI.
The team analysed a series of 164 images from each of 114 individuals and discovered the brain scans of the social perception circuits only indicated ASD in boys. As the method only works for boys with autism, the researchers are leading a large-scale, nationwide study of girls with autism to identify equivalent techniques that will work for them.