Providing a diet rich in carbohydrates immediately after the birth of a baby could program it to obesity even if calorie intake is reduced in adulthood, a new study reveals.
The study suggested that human babies might be less prone to obesity if given solid foods later.
This is the first time that we have shown in our rat model of obesity that there is a resistance to the reversal of this programming effect in adult life, explained Mulchand S. Patel, PhD, SUNY Distinguished Professor of Biochemistry and associate dean for research and biomedical education in the University at Buffalo School of Medicine and Biomedical Sciences.
The research has applications to the obesity epidemic, particularly as it relates to infant nutrition, Patel explained.
"Our hypothesis has been that the introduction of baby foods too early in life increases carbohydrate intake, thereby boosting insulin secretion and causing metabolic programming that in turn, predisposes the child to obesity later in life," he said.
For more than 20 years, Patel and his UB colleagues have studied how the increased intake of carbohydrate-enriched calories just after birth can program individuals to overeat.
For their rat model of obesity, the UB researchers administered to newborn rat pups special milk formulas they developed that are either similar to rat milk in composition, (higher in fat-derived calories) or enriched with carbohydrate-derived calories.
"These pups who were fed a high-carbohydrate milk formula are getting a different kind of nourishment than they normally would," explained Patel, "which metabolically programs them to develop hyperinsulinemia, a precursor for obesity and type 2 diabetes."
At three weeks of age, the rat pups fed the high-carbohydrate (HC) formula were then weaned onto rat chow either with free access to food or with a moderate calorie restriction, so that their level of consumption would be the same as pups reared naturally.
"When food intake for the HC rats was controlled to a normal level, the pups grew at a normal rate, similar to that of pups fed by their mothers," Patel said.
"But we wanted to know, did that period of moderate calorie restriction cause the animals to be truly reprogrammed? We knew that the proof would come once we allowed them to eat ad libitum, without any restrictions.
"We found that when the HC rat undergoes metabolic reprogramming for development of obesity in early postnatal life, and then is subjected to moderate caloric restriction, similar to when an individual goes on a diet, the programming is only suppressed, not erased," he stated.
This is due to developmental plasticity, which extends from fetal development into the immediate postnatal period. According to Patel, previous research by others has revealed that during the immediate postnatal period, pancreatic islets and neurons continue to mature.
"That's why an altered nutritional experience during this critical period can independently modify the way certain organs in the body develop, resulting in programming effects that manifest later in life," Patel noted.
"During this critical period, the hypothalamus, which regulates appetite, becomes programmed to drive the individual to eat more food. We found that a period of moderate caloric restriction later in life cannot reverse this programming effect," he added.
Therefore, he noted, addressing the obesity epidemic requires true lifestyle change, including permanent caloric restriction.
"As long as you restrict intake, you can maintain normal body weight," he said.
To avoid metabolic reprogramming that predisposes a baby to obesity later in life, he advised that parents should follow the American Academy of Pediatric guidelines, which state that solid foods should not be given before a baby is 4-6 months old.
The result was published this month in the American Journal of Physiology: Endocrinology and Metabolism.