New Study Sheds Light On Cancer Of The Appendix

by VR Sreeraman on  March 11, 2012 at 9:32 PM Cancer News   - G J E 4
Researchers have demonstrated the difference between the cancer of the appendix and colon cancer, a distinction that could lead to more effective treatments for both diseases.
 New Study Sheds Light On Cancer Of The Appendix
New Study Sheds Light On Cancer Of The Appendix

The study by Edward A. Levine, M.D., professor of surgery and chief of the surgical oncology service at Wake Forest Baptist, is the result of gene analysis of cases covering a 10-year period.

It appears in the early online edition of the April issue of the Journal of the American College of Surgeons.Cancer of the appendix, which is part of the colon, affects approximately 2,500 people in the United States annually and has the propensity to spread throughout the peritoneal cavity, the space within the abdomen that contains the intestines, stomach and liver.

"Our treatment program, which was the catalyst for this research, is one of the largest worldwide and consists of aggressive surgery coupled with heated chemotherapy placed directly into the abdominal cavity at the time of surgery," Levine said.

"Given the uncertainty of predicting outcomes in patients with disseminated appendiceal cancer, we sought to use the tools of gene expression profiling to better understand these rare malignancies at a molecular level in order to better predict oncologic outcomes.

We've looked at the genes that make these cancers tick, and we actually started to pick them apart for the first time."For the study, the researchers examined tumor samples from Wake Forest Baptist's tissue bank for patterns of expression of different genes.

"By looking at these genetic signatures, we found that the genes active in cancer of the colon and those active in cancer of the appendix are very different," Levine said. "For years, however, cancer of the appendix, which is part of the colon, has been treated with the same chemotherapy treatment used for colon cancer.

This study shows that we need a fresh approach to how we treat appendix cancer."

Source: Eurekalert

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

View All