New Source of Botox Found in Strain of Animal Gut Bacteria

by Chrisy Ngilneii on  January 27, 2018 at 3:30 PM Drug News
RSS Email Print This Page Comment bookmark
Font : A-A+

A new source of Botox has been found in a strain of animal gut bacteria known as Enterococcus faecium.

The neurotoxic protein is known for its paradoxical ability to remove wrinkles yet cause botulism, a potentially fatal illness associated with food poisoning.
New Source of Botox Found in Strain of Animal Gut Bacteria
New Source of Botox Found in Strain of Animal Gut Bacteria

Over the past 20 years, there has also been a growing number of therapeutic applications for botulinum toxin type A, known as Botox, including treatment for migraines, leaky bladders, excessive sweating, and cardiac conditions.

"This is the first time that an active botulinum toxin has been identified outside of Clostridium botulinum and its relatives, which are often found in soil and untreated water," said Andrew Doxey, one of the study's two corresponding authors and a bioinformatics professor at the University of Waterloo. "Its discovery has implications in several fields, from monitoring the emergence of new pathogens to the development of new protein therapeutics, it's a game changer."

Doxey's findings were developed in collaboration with researchers from Harvard University and the Boston Children's Hospital.

In the study, originally designed to investigate the origins of antibiotic resistance in E. faecium bacteria, the researchers were able to sequence the genome of the E. faecium bacteria drawn from cow feces. The genome was then run through computer programs in Doxey's lab, which found the gene for botulinum toxin in the bacterial strain.

The research team concluded that the botulinum toxin was likely transferred from C. botulinum bacteria in the environment into the E. faecium bacteria in the cow's gut, showing that the toxin can be transferred between very different species.

"The botulinum toxin is a powerful and versatile protein therapeutic" says Michael Mansfield, a Biology doctoral candidate in the Doxey Lab and one of the study's lead authors. "By finding more versions of the toxin in nature, we can potentially expand and optimize its therapeutic applications even further."

Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

Related Links

More News on:

Torticollis Shigellosis Botox Face Lift (Rhytidectomy) Anti-aging Secrets to a Younger You MRSA - The Super Bug Cosmetic Surgery and the Risk Factors Probiotics - Support System for the Gut Food Safety for Health Antibiotics 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive

Loading...