Pancreatic Cancer - All About the Disease, its Diagnosis and Management
Pancreatic cancer often involves its exocrine part. It grows aggressively, and often detected late. Treatment options include surgery, radiation and chemotherapy.
Pancreatic cancer often involves its exocrine part. It grows aggressively, and often detected late. Treatment options include surgery, radiation and chemotherapy.
‘Using a therapeutic compound, called SapC-DOPS, a nanovesicle (or a nanotechnology drug delivery system) made of microscopic components of a cell, to deliver a combined biomarker target therapy and standard chemotherapy for pancreatic cancer may show benefit to patients.’
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"These research findings will help us lead a clinical trial with a combination therapeutic approach to treat pancreatic cancer patients," says Qi, corresponding author on the paper and a member of the UC Cancer Center. "Only a small number of promising drugs target pancreatic cancer, which is the fourth-leading cause of cancer deaths, with a five-year survival of less than six percent," Qi says. "Pancreatic cancer is usually asymptomatic in the early stages, while frequently invading lymph nodes and the liver, and less often the lungs and visceral organs. Current treatments, including surgery, chemotherapy and radiation therapy, have failed to improve long-term survival.
"We've discovered a drug-targetable biomarker (phosphatidylserine) for pancreatic cancer cells in previous studies, and one of the first line treatments for advanced pancreatic cancer is chemotherapy, but it only provides marginal improvements for patients. We wanted to see if we could use the current first line treatment in combination with the novel nanovesicle drug delivery to improve outcomes."
Quiz on Pancreatic Cancer
Pancreatic cancer is often diagnosed at a late stage and can be fatal. Test your knowledge on pancreatic cancer by taking this quiz.
Pancreatic cancer is often diagnosed at a late stage and can be fatal. Test your knowledge on pancreatic cancer by taking this quiz.
In this study, researchers used both animal models and human cancer cells to test this theory and found that the combination of these therapies together helped to target the biomarker on cancer cell surface at various points in their life cycle, ultimately inhibiting tumor growth and potentially increasing survival, in comparison to the treatments alone.
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Pancreatic Cancer Metastasis: New Findings
In pancreatic cancer metastasis, when tumor cells gain the deadly ability to migrate to new parts of the body can be suppressed by inhibiting a protein called Slug that regulates cell movement, said scientists.
In pancreatic cancer metastasis, when tumor cells gain the deadly ability to migrate to new parts of the body can be suppressed by inhibiting a protein called Slug that regulates cell movement, said scientists.
Source-Eurekalert
Diabetes 3c Is An Early Manifestation of Pancreatic Cancer
Diabetes type 3c or pancreatogenic diabetes, could be an early manifestation of pancreatic cancer, according to the Genetic and Molecular Epidemiology Group, led by Núria Malats at the Spanish National Cancer Research Centre.
Diabetes type 3c or pancreatogenic diabetes, could be an early manifestation of pancreatic cancer, according to the Genetic and Molecular Epidemiology Group, led by Núria Malats at the Spanish National Cancer Research Centre.
