Most Popular News on Medindia

P
M

New Non-Antibiotic Approach For Treating Urinary Tract Infections

by Rukmani Krishna on  June 23, 2012 at 6:12 AM General Health News   - G J E 4
Journal of Medicinal Chemistry.'>
A potential new approach for treating urinary tract infections (UTIs) without traditional antibiotics is being reported in ACS' Journal of Medicinal Chemistry. UTIs affect millions of people annually. This approach involves so-called FimH antagonists, which are non-antibiotic compounds and would not contribute to the growing problem of antibiotic resistance bacteria.
 New Non-Antibiotic Approach For Treating Urinary Tract Infections

Beat Ernst and colleagues explain that antibiotics are the mainstay treatment for UTIs. Bacteria, however, are developing resistance to common antibiotics, with the emergence of "superbugs" that shrug off some of the most powerful new antibiotics. Thus, the scientists decided to try a new approach — developing substances that target bacteria virulence factors, inhibiting them from sticking to the inside of the urinary bladder. Hence, microbes are not able to launch an infection and, furthermore, this new class of antimicrobials is expected to exhibit less selection pressure and, therefore, a reduced potential for the emergence of resistance.

The scientists describe the development of anti-adhesion molecules that specifically interfere with the attachment of bacteria to human bladder cells. The most potent of the substances, an indolinylphenyl mannoside, prevented a UTI from developing in mice (stand-ins for humans in this kind of experiment) for more than eight hours. In the in vivo treatment study, a very low dose of 25 µg per mouse reduced the amount of bacteria in the bladder of the animals by almost 10,000 times, which is comparable to the standard antibiotic treatment with ciprofloxacin.

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

Ask an Expert

C
If you have a question about health related issues, you can now post it in our Ask An Expert section on our community website Medwonders.com and get answers from our panel of experts.
X

Ask an Expert

Ask an Expert+
s
Effective Way to Reduce Smoking in Pregnant Women
 Effective Way to Reduce Smoking in Pregnant Women
S  New Prognosis Tool for Deadly Brain Cancer Shown By UW Research
New Prognosis Tool for Deadly Brain Cancer Shown ...