The eye skin ages faster than the surrounding facial skin. The Estée Lauder Companies (NYSE: EL) Research & Development
(R&D) announced a new biomechanical eye model that mimics mechanical
stress on peri-orbital skin from the blinking movement to study the
cellular impact as a function of age.
These data were presented during
the Late-breaking Research Forum at the 75th Annual Meeting of the
American Academy of Dermatology (AAD).
‘A new biomechanical eye model mimics mechanical stress on peri-orbital skin from the blinking movement to study the cellular impact as a function of age.’
The Estée Lauder Companies R&D have been working at the
convergence of physics and biology to gain new insight into how skin
cells are impacted by biomechanical stress. This approach led to a new
model that showed for the first time how aged cells do not respond as
well to eyes' constant micro-movement, and how both young and aging
cells are impacted by this cyclic mechanical stress with blinking.
Results over time show a loss of natural cell reorganization, collagen
production, and energy, as well as an increase in inflammation and
slower cellular proliferation. These stresses, induced by a profound
level of repetitive tissue movements that impact skin cells and
scaffolding, along with the unique structure of the periorbital skin,
explain why eye skin ages faster than the surrounding facial skin.
"Understanding how cells sense their environment, and respond to its
mechanical properties by altering patterns of protein expression as
well as other cellular functions, represents an important discovery in
skin science research," said Dr. Nadine Pernodet, Vice President of Skin
Biology and BioActives Research & Development, Estée Lauder
Companies Research & Development.
"Instead of only focusing on the
unique structural characteristics of eye skin, this new biomechanical
model shows that maintenance of the extracellular matrix is diminished
and skin cell functions are compromised due to the natural repetitive
tissue movements around the eye, thus accelerating skin aging."
This new biomechanics approach is the latest breakthrough in The
Estée Lauder Companies' industry-leading skin research. After
revolutionizing research in the cosmetic industry with the importance of
DNA repair, the importance of circadian rhythm, the importance of
epigenetics for skin youth and the damages from pollution, The Estée
Lauder Companies are now leveraging the intersection of biology and
physics to understand skin behavior through biomechanics-mechanobiology.