New Method Could Soon Be The Cure For Jet Lag

by Shirley Johanna on  May 30, 2016 at 6:58 PM Research News
RSS Email Print This Page Comment
Researchers at Nagoya University's Institute of Transformative Bio-Molecules (ITbM) in Japan, have designed new molecules that can help modify the human biological clock to manage sleep as well as improve treatment for jet lag and sleep disorders.
New Method Could Soon Be The Cure For Jet Lag
New Method Could Soon Be The Cure For Jet Lag

Most living organisms, including humans, have a circadian rhythm or the 24-hour biological clock that regulates functions such as sleep-wake cycles, hormone secretion, and metabolism.

This cycle often gets disrupted in situations like jet lag and sleep disorders like sleep apnea where long-term sleep loss ensues. This may affect cardiovascular, endocrine, immune and nervous systems with severe consequences including hypertension, obesity, and mental health disorders, among others.

"We can make bioactive molecules that can control the circadian rhythm of animals and gain further insight into the circadian clock mechanism which will surely contribute to medical applications, food production and advances in clock research," said Takashi Yoshimura, a professor at Nagoya University's Institute of Transformative Bio-Molecules (ITbM) in Japan.

The team synthesized the activity of circadian rhythm-changing molecules and targeted a molecule that affects a specific circadian protein called CRY.

The findings showed that FBLX3 -- a compound that readies protein CRY for degradation by cellular enzyme -- competes with KL001 -- a molecule that lengthens the circadian cycle -- to preventing its degradation.

They prepared compounds that were similar to KL001, thus synthesizing the first circadian shortening molecules that target the CRY protein.

The negative impacts of jet lag and shift work could be significantly reduced if it were possible to reset our 24-hour natural circadian or sleep/wake cycle with the discovery, the authors noted.

Source: IANS

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
* Your comment can be maximum of 2500 characters
Notify me when reply is posted
I agree to the terms and conditions

More News on:

Melatonin Top 10 Ways to Prevent Jet Lag / Desynchronosis Five Interesting Ways to Overcome Post-Holiday Blues 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive