Medindia

X

New Hope for Understanding Fatal Infections

by Bidita Debnath on  July 22, 2016 at 1:35 AM Research News   - G J E 4
Mucorales fungi causes a fatal infection in ever-increasing segments of patient population. Research published in the journal, Nature Communications, provides new insights into the evolution of Mucorales fungi and several molecular pathways that might be exploited as potential therapeutic or diagnostic targets.
 New Hope for Understanding Fatal Infections
New Hope for Understanding Fatal Infections
Advertisement

Mucorales invades the cells of people with weakened immune systems and causes the deadly infection, mucormycosis. The study, conducted by LA BioMed and the University of Maryland School of Medicine researchers, identified several pathways that are required for mucormycosis to develop in a patient.

‘To halt the highly fatal mucormycosis infection, there are no vaccines or effective therapies available today. There is an urgent need for additional research to develop strategies to protect patients with weakened immune systems.’
Advertisement
"Our research opens the door for identifying and targeting the specific pathways that are required for the development of mucormycosis," said Ashraf S. Ibrahim, PhD, an LA BioMed lead researcher and a contributing author for the study. "The generated data could then be exploited to design novel strategies to pursue treatment, prevention and/or early diagnosis of mucormycosis."

The researchers reported on the sequencing of 30 isolates of Mucorales and the study of the transcriptomes of three most common causes of mucormycosis, in response to lung epithelial cells. They identified several pathways that are required for mucormycosis pathogenesis.

Those most at risk of mucormycosis are patients with uncontrolled diabetes ketoacidosis, other forms of metabolic acidosis, treatment with corticosteroids, solid organ or bone marrow transplantation, neutropenia, trauma and burns, such as those suffered by wounded soldiers in Iraq and Afghanistan, malignant hematological disorders and deferoxamine therapy in patients receiving hemodialysis.

Cutaneous necrotizing soft tissue mucormycosis outbreaks in otherwise healthy individuals have also been known to follow natural disasters, as evidenced by the Apophysomyces infections, usually associated with trauma, following the tsunami that devastated Indonesia in 2004 and the tornadoes that occurred in Joplin, MO in June 2011.

"There are no vaccines or effective therapies available today to halt the highly fatal mucormycosis infection," Dr. Ibrahim said. "There is an urgent need for additional research to develop strategies to protect patients with weakened immune systems."

Source: Eurekalert
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All