New Gene Variants Found in Gut Disease In Children Under Age Five

by Bidita Debnath on  September 6, 2015 at 11:53 PM Research News   - G J E 4
After analyzing the complicated genetic influences in inflammatory bowel disease (IBD), researchers have discovered new gene variants associated with an often-severe type of the disease that affects children under the age of five.
 New Gene Variants Found in Gut Disease In Children Under Age Five
New Gene Variants Found in Gut Disease In Children Under Age Five

"As we continue to understand the specific functions of these genes in this type of childhood-onset disease, we are working to design more effective therapies," said study leader Judith Kelsen from The Children's Hospital of Philadelphia (CHOP), US.

Inflammatory bowel disease (IBD) is a painful, chronic inflammation of the gastrointestinal tract.

In fact, very early-onset IBD (VEO-IBD), diagnosed under age five, is often more severe than IBD that starts later in childhood.

"There has been extensive research in the genes contributing to adult-onset IBD and in children aged 10 and older but relatively little research has been performed in the very-early onset subtype of the disease," Kelsen said.

The study team analyzed DNA from 125 children with VEO-IBD, all of them under age four, along with DNA from 19 of their parents.

A control group of 210 participants included 145 healthy individuals, 45 patients with pediatric IBD and 20 with adult-onset Crohn's disease (one of the two major types of IBD).

The researchers found rare and novel variants in genes that regulate B-cells and T-cells -- immune cells with important roles in immunodeficiency disorders.

They also discovered rare variants in the IL10RA gene, a member of a key immune function pathway.

The findings were published online in the journal Gastroenterology.

Source: IANS

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