New Drug Reduces Heart Damage During Surgery

by Sheela Philomena on  March 12, 2013 at 10:17 AM Clinical Trials News   - G J E 4
A single dose of an anti-inflammatory treatment was found to reduce heart muscle damage during angioplasty procedures, says study.
 New Drug Reduces Heart Damage During Surgery
New Drug Reduces Heart Damage During Surgery

The antibody inclacumab, developed by Swiss lab Hoffmann-La Roche, significantly reduced levels of the standard molecular markers troponin I and CK-MB in patients, compared to those who took a placebo in a clinical trial.

Patients who received the inclacumab dose saw troponin I levels drop 22.4 percent more after 16 hours and 24.4 percent after more at 24 hours (p=0.05), compared with patients on a placebo.

CK-MB levels dropped 16.3 percent more after 16 hours and 17.4 percent more at 24 hours, compared with patients on placebo.

"It was exciting to see that a single administration of inclacumab would yield clinical benefit," said the study's lead investigator Jean-Claude Tardif, director of the Research Center at the Montreal Heart Institute.

The phase II trial examined 530 patients with a median age of 61 experiencing a type of heart attack called non-ST-elevation myocardial infarction or NSTEMI.

Patients were randomized to receive an infusion of inclacumab of 20 milligrams per kilogram, five milligrams per kilogram or a placebo one hour before angioplasty.

The researchers also found that 24 hours after angioplasty, 18.3 percent of patients on the placebo had CK-MB increases more than three times the upper limit of normal.

Many clinical trials define that threshold as the onset of a post-angioplasty heart attack.

But only 8.9 percent of patients who received the higher dose of inclacumab experienced those same CK-MB increases.

"If we're able to confirm these results in potential future studies, this drug could become part of the therapeutic armamentarium in modern cardiology," Tardif said in a statement.

"You could use this drug more widely, in all patients coming in with heart attacks, although that would require additional large studies."

More than a million coronary angioplasty procedures are performed in the United States each year, costing more than $10 billion.

Angioplasty can damage heart tissue, which can trigger a need for more procedures, poor outcomes and higher health care costs .

During angioplasty, surgeons insert a balloon catheter to mechanically widen narrowed or obstructed arteries.

Source: AFP

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