An orthopedic implant is often used to replace a missing joint or bone or to support a damaged bone. There have been media reports of people having allergic reactions to the metals used in joint implants.
To understand the molecular mechanisms involved in the interaction of
bone with orthopedic implants comprised of novel biomaterials,
researchers have made a mouse model in which they can assess early
tissue responses to surfaces such as bioactive glass.
‘A newly developed mouse model enables researchers to understand the molecular mechanisms involved in the interaction of bone with orthopedic implants comprised of novel biomaterials.’
The ease of
genetically modifying this mouse model makes it especially valuable in
designing novel biomaterials for use in regenerative medicine, as
describe in an article published in Tissue Engineering, Part C Methods
, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.
The article entitled "A Bone-Implant Interaction Mouse Model for Evaluating Molecular Mechanism of Biomaterials/Bone Interaction"
is coauthored by Wenlong Liu and colleagues from Shenzen
Institutes of Advanced Technology, Chinese Academy of Sciences, The
University of Hong Kong, and The Chinese University of Hong Kong,
Shenzhen, China. They present results demonstrating the feasibility and
reliability of the mouse model using various biomaterials.
"This very accessible and elegant model brings the assessment of bone replacing biomaterial to a new level," says Tissue Engineering, Part C: Methods
Co-Editor-in-Chief John A. Jansen, Professor Dentistry -
Biomaterials, Radboud University Medical Center, Nijmegen, Netherlands.