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New Antibiotic Drug from Soil Bacterium to Treat Drug-resistant TB

by Thilaka Ravi on  September 19, 2012 at 8:11 PM Drug News   - G J E 4
A promising new drug is being developed with a natural product secreted by a soil bacterium to treat tuberculosis.

A team of scientists working in Switzerland has shown how pyridomycin, a natural antibiotic produced by the bacterium Dactylosporangium fulvum, works.
New Antibiotic Drug from Soil Bacterium to Treat Drug-resistant TB
New Antibiotic Drug from Soil Bacterium to Treat Drug-resistant TB
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This promising drug candidate is active against many of the drug-resistant types of the tuberculosis bacterium that no longer respond to treatment with the front-line drug isoniazid.

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"Nature and evolution have equipped some bacteria with potent defense mechanisms to protect them against other bugs that share their habitat. Screening natural products generated by these organisms is therefore a powerful way to find possible new drugs to fight infectious diseases," Stewart Cole, lead author of the study, EMBO Member and a professor at the Ecole Polytechnique Federale de Lausanne (EPFL), Switzerland, said.

"Using this approach we have shown that nature's antibiotic pyridomycin is a very selective killer of Mycobacterium tuberculosis, the bacterium responsible for tuberculosis in humans.

"It is also active against mycobacteria that have developed resistance to front-line drug treatments such as isoniazid," he said.

Tuberculosis causes up to two million deaths annually.

The findings are published in EMBO Molecular Medicine.

Source: ANI
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