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Neurotoxicity of Colistin Sulfate Is Effectively Inhibited By Baicalin

by Rukmani Krishna on  December 10, 2013 at 1:56 AM Research News   - G J E 4
Baicalin is a type of flavonoid extracted from the dried root of Scutellaria baicalensis georgi. It has been shown to effectively inhibit cell apoptosis. Colistin sulfate, a cyclic cationic polypeptide antibiotic, has been shown to have renal and neurological side effects.
 Neurotoxicity of Colistin Sulfate Is Effectively Inhibited By Baicalin
Neurotoxicity of Colistin Sulfate Is Effectively Inhibited By Baicalin
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Dr. Hong Jiang and colleagues from Northeast Agricultural University assumed that baicalin would suppress colistin sulfate-induced neuronal apoptosis. In a study by Jiang et al, PC12 cells were pretreated with baicalin (25, 50 and 100 μg/mL), and exposed to 125 μg/mL colistin sulfate. Cell morphology markedly changed, and cell viability increased. Moreover, caspase-3 activity, lactate dehydrogenase level and free radical content decreased. Experimental results indicated that baicalin inhibited colistin sulfate-induced PC12 cell apoptosis by suppressing free radical injury, and reducing caspase-3 activity and lactate dehydrogenase activity. These findings are published in the Neural Regeneration Research (Vol. 8, No. 28, 2013).

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Source: Eurekalert
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