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Natural Compound Reduces Potency of HIV; Thereby Halting the Progression of AIDS

by Dr. Trupti Shirole on  July 9, 2015 at 11:38 PM AIDS/HIV News   - G J E 4
Patients infected with Human Immunodeficiency Virus (HIV) remain on antiretroviral therapy for life because the virus survives over the long-term in infected dormant cells. Interruption of presently available antiretroviral therapy results in a rebound of HIV and clinical progression to Acquired Immuno Deficiency Syndrome (AIDS). Researchers have discovered that supplementing this existing antiretroviral therapy with a natural compound, called Cortistatin A, can reduce the potency of HIV, thereby halting the progression of AIDS.
Natural Compound Reduces Potency of HIV; Thereby Halting the Progression of AIDS
Natural Compound Reduces Potency of HIV; Thereby Halting the Progression of AIDS
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Lead researcher Susana Valente, associate professor at The Scripps Research Institute (TSRI) in the US, said, "Our results highlight an alternative approach to current anti-HIV strategies."

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The researchers have detailed that unlike other antiretroviral therapies, Cortistatin A reduces residual levels of virus from the HIV-infected dormant cells, establishing a near-permanent state of latency and greatly diminishing the virus' capacity for reactivation.

Valente said, "Prior treatment with Cortistatin A significantly inhibits and delays viral rebound in the absence of any drug. Our results suggest current antiretroviral regimens could be supplemented with a Tat inhibitor such as Cortistatin A to achieve a functional HIV-1 cure, reducing levels of the virus and preventing reactivation from latent reservoirs."

For the study, the researchers isolated cells from nine HIV-infected patients being treated with antiretroviral drugs. They found that treatment with the natural molecule reduced viral reactivation by an average of 92.3%.

The study is published in mBio.

Source: IANS
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