Healing of wounds take time but researchers at the Albert Einstein College of Medicine, a part of Yeshiva University, are using novel nanoparticles to significantly speed up the wound-healing process.
The investigators developed a silencing RNA (siRNA) drug that inhibits the gene responsible for the production of fidgetin-like 2 (FL2). FL2 is a naturally produced enzyme and slows down the migration of cells as they travel toward a wound site.
In order to deliver the siRNA into the interior of cells, it was encapsulated in specially designed nanoparticles. These nanoparticles prevented disruption and kept their cargo fresh and intact before reaching the cell and letting it flow out.
Clinical trials done to check the effect of the nanoparticles revealed that topical application of FL2 siRNA nanoparticles enhanced the quality and speed of wound healing.