Become a member
Quick Registration
Full Registration Benefits -
Free Homepages for Doctors
Free Homepages for Hospitals
Free Homepages for Medical Conference
Free Homepages for NGO's
Personal Health Record Creation
Access to all Medical Slides
Access to all Jobs & Products Sale
More Potent Typhoid Shots Being Developed By Indian-American | |
|
| |
The first mouse model of typhoid fever could help in creating more potent vaccines against the deadly pathogen. The model was developed by an Indian-American microbiologist and colleagues.
"The two vaccines currently approved for this disease (typhoid) are only modestly effective, so research aimed at improving vaccines is essential," says senior study author Sankar Ghosh of Columbia University.
Ghosh did his M.Sc from the University of Calcutta and MS and Ph.D from Albert Einstein College of Medicine, New York (Yeshiva University).
"Prior to our work, there was no small animal model for studying immune responses to the bacteria that cause typhoid fever," says study co-author Matthew Hayden of Columbia. "We hope that the model we have developed will promote rapid progress in developing better vaccines," the journal Cell reports.
Typhoid fever is characterised by rashes and severe diarrhoea. It causes over 220,000 deaths each year, mostly in developing countries lacking clean sources of drinking water.
It is caused by the bacterium Salmonella typhi (S. Typhi), which normally infects humans but not mice, according to a Columbia statement.
Unlike humans, mice express TLR11, an immune cell receptor that recognises molecules found in a range of microbes and triggers immune responses that help to fight infections.
Because TLR11 is highly expressed in the mouse intestine, Hayden and his colleagues suspected that this receptor might recognise pathogens that cause intestinal diseases and could be responsible for preventing typhoid fever in mice.
To answer these questions, the researchers inactivated the TLR11 gene in mice and exposed them to S. Typhi.
Exposed mice developed severe intestinal tissue damage and hallmark symptoms like fever and diarrhoea. But when the mice were first immunised with heat-killed S. Typhi, they mounted strong immune responses and became impervious to infection.
"Having an animal model vastly improves our ability to investigate diseases, the immune response and, importantly, can be immensely beneficial for efforts to develop new vaccines and therapies," Hayden says.
Source-IANS
| |
|
|
 Comment & Contribute
|
Related Links
An Animal Model of Typhoid Fever Could Lead to Better Vaccines: Study
In a new study the first mouse model of the common bacterial disease typhoid fever is reported. The study is published by Cell Press October 25 in ...
New Finding may Help Combat Typhoid Fever-Causing Bacteria
Scientists in the UK have identified a switch that enables Salmonella bacteria to sabotage host cells. Researchers from Imperial ...
Underused Vaccine Against Typhoid Fever Is Highly Effective In Young Children
A currently available yet underused vaccine against typhoid fever is highly effective in young children and protects unvaccinated neighbors of ...
First Mouse Model of Typhoid Fever
The first true mouse model of typhoid infection has been created by Columbia University Medical Center (CUMC) researchers. The ...
General News
Coronavirus Claims New Life in Saudi Arabia
The health ministry announced on its website that a man who had contracted the coronavirus has died in Saudi Arabia, raising the death toll in the ...
Concept Vaccine may Protect Against Flu
Scientists unveiled a concept vaccine against flu that they said may protect against various strains with a single jab. Tested in ...
Life Expectancy Gap Widens Among Mental Illness Patiets
Among mental illness, the association of higher death rate has been extensively documented, but most of the attention has focused on the elevated ...
Glaucoma Drug can Cause Droopy Eyelids: Study
Prostaglandin analogues (PGAs) are drugs which lower intraocular pressure. PGAs are often the first line of treatment for people with glaucoma, but ...
Early-life Traffic-related Air Pollution Exposure Linked to Hyperactivity: Research
According to new research from the University of Cincinnati (UC) and Cincinnati Children's Hospital Medical Center, early-life exposure to ...
Telerehabilitation Allows Accurate Assessment of Patients With Low Back Pain: Study
A study in the May 15 issue of Spine reports that a new "telerehabilitation" approach lets physical therapists assess patients with low ...
- Health News Index
- News Quick Links
| News Categories: |
| » | Dietary Advice on Added Sugar 'Damaging Our Health', Says Expert |
| » | What is the Similarity Between Sugary Syrup and Cocaine? |
| » | Tapping into the World of Bugs to Solve Food Demand |
| » | Susceptibility to E. Coli Infection may be Increased by High Fiber Diets |
| » | Mothers Diet During Pregnancy Determines Likelihood of Obesity and Heart Disease in Future Life |
| More Diet News | |
|
Ask an Expert
