Medindia

X

Monoclonal Antibody Therapy Induces Macrophages to Target Tumor Cells

by Kathy Jones on  January 18, 2014 at 10:40 PM Cancer News   - G J E 4
Extensive research has shown that monoclonal antibodies directed against tumor antigens have proven effective for treating some forms of cancer.
 Monoclonal Antibody Therapy Induces Macrophages to Target Tumor Cells
Monoclonal Antibody Therapy Induces Macrophages to Target Tumor Cells
Advertisement

Despite the increasing use of monoclonal antibody therapy, it is not clear how these antibodies drive tumor removal. In this issue of the Journal of Clinical Investigation, Marjolein van Egmond and colleagues at the VU University Medical Center found that macrophage populations mediate tumor cell removal following monoclonal antibody treatment by actively phagocytosing tumor cells. Macrophage-dependent tumor cell removal required both the high affinity and low affinity Fc receptors. This study suggests that monoclonal antibody therapies that are optimized to enhance macrophage recruitment and activity may enhance removal of circulating tumor cells in cancer patients.

Advertisement


Source: Eurekalert
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All