Medindia

X

Metabolite Retention May Cause Cognitive Impairment in Kidney Failure Patients

by Dr. Trupti Shirole on  July 25, 2016 at 10:56 PM Research News   - G J E 4
In patients with compromised kidney function, the retention of compounds that are normally removed from the body and excreted in urine may contribute to various health problems. Retention of certain metabolites in the blood may contribute to cognitive impairment in patients with kidney failure, revealed a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN).
 Metabolite Retention May Cause Cognitive Impairment in Kidney Failure Patients
Metabolite Retention May Cause Cognitive Impairment in Kidney Failure Patients
Advertisement

The findings may lead to interventions to safeguard the mental health of patients with poor kidney function. To investigate a potential link between retained metabolites and cognitive impairment, Manjula Kurella Tamura (Stanford University and Veterans Affairs Palo Alto) and her colleagues analyzed the blood of 141 patients with kidney failure who took tests on cognitive function.

‘Retention of certain metabolites in the blood may contribute to cognitive impairment in patients with kidney failure.’
Advertisement
Levels of four metabolites in the blood- 4-hydroxyphenylacetate, phenylacetylglutamine, hippurate, and prolyl-hydroxyproline- were associated with impaired cognitive function. The first three are primarily produced by bacteria that reside in the gut. When the researchers screened for the metabolites in an additional 180 patients with kidney failure, the association between 4-hydroxyphenylacetate and impaired cognitive function was replicated.

"This metabolite has been previously linked to cognitive impairment in patients with liver failure and in patients with inborn errors of urea synthesis," said Dr. Tamura. "We believe these findings are timely, given recent interest in the role of the gut microbiome in human disease."

Source: Newswise
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All