Married Couples Appearing Similar? They Could Be Sharing Genes

by Hannah Joy on  April 7, 2017 at 1:03 PM Genetics & Stem Cells News
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Married couples appearing similar is definitely not a coincidence. Rather it is linked to marrying someone from the same ancestry. This has an important effect on the genes of various population groups, reveals a study.
Married Couples Appearing Similar? They Could Be Sharing Genes
Married Couples Appearing Similar? They Could Be Sharing Genes

The study was reported by Ronnie Sebro of the University of Pennsylvania, and senior authors Josee Dupuis from the Boston University School of Public Health and Neil Risch from the University of California, San Francisco.

Until recently, most people picked a spouse from within their local community, and that person often had the same ancestry. Over many generations, this affinity for similar mates has created a genetic structure in the population which has the potential to bias the results of genetic studies.

In the first investigation into mating patterns across multiple generations within a U.S. population, researchers explored genetic similarity between spouses from three generations of white people in the Framingham Heart Study, an ongoing examination of heart health in the residents of Framingham, Massachusetts, which began in 1948.

Using genomic data, they characterized the ancestry of 879 participant spouse pairs and observed that individuals of Northern European, Southern European and Ashkenazi ancestry preferentially chose spouses of the same background.

In each successive generation, however, individuals were less likely to choose a spouse with the same ancestry. They also showed that the mating patterns caused spouses to be more genetically similar to each other than might otherwise be expected, and that the genetic structure created by these mating patterns in the population has decreased over time.

The findings from this study reflect demographic patterns and how they have changed during the past 60 years in Framingham, Massachusetts. Genetic similarity within a population can be important to consider in genomic studies because it can lead to false positives when identifying gene regions that are associated with a disease, and affect estimates of the degree to which a disease is passed on through one's genes. The study is published in PLOS Genetics.



Source: ANI

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