Researchers at the Houston Methodist Research Institute have developed a new technique to deliver a high concentration of drug directly to the clot site.
Magnetic nanoparticles can dissolve faster in magnitude than direct injections. This endovascular clot retrieval might become the standard future treatment for ischemic strokes.
The nanoparticles are coated with iron oxide and albumin, so that the immune system does not immediately target them.
The nanoparticles are readily seen under MRI and can be steered using an external magnetic guidance system, as they are magnetic. The magnet can induce a high frequency vibration of the nanoparticles, heating them up to clot destruction.
The thrombolytic tPA was the commonly used tissue plasminogen activator while nanoparticles are being tested in a laboratory environment involving mice and human blood.