Lung Disease in Preterm Infants can be Managed With Stem Cells

by Himabindu Venkatakrishnan on  February 6, 2014 at 10:01 PM Research News
RSS Email Print This Page Comment
Stem cells have found to be a safe and feasible treatment for preterm infants with bronchopulmonary dysplasia (BPD), in a new study scheduled for publication in The Journal of Pediatrics. However, preterm infants have an increased risk of developing bronchopulmonary dysplasia (BPD), a serious lung disease, which is a major cause of death and lifelong complications. In this study, researchers evaluated the safety and feasibility of using stem cell therapies on very preterm infants to prevent or treat BPD.
 Lung Disease in Preterm Infants can be Managed With Stem Cells
Lung Disease in Preterm Infants can be Managed With Stem Cells

Won Soon Park, MD, PhD, and colleagues from Samsung Medical Center and Biomedical Research Institute, Seoul, Republic of Korea, conducted a phase I, single-center trial of intratracheal transplantation of human umbilical cord blood-derived mesenchymal stem cells to nine very preterm infants (24-26 weeks gestational age) who were at high risk of developing BPD.

All patients who received the treatment tolerated the procedure well without any immediate serious adverse effects. Thirty-three percent of treated infants developed moderate BPD and none developed severe BPD, and 72 percent of a matched comparison group developed moderate or severe BPD. Another serious side effect of very preterm birth, retinopathy of prematurity requiring surgery, tended to occur less often in treated infants. Overall, all nine treated infants survived to discharge, and only three developed moderate BPD.

This phase I study suggests that intratracheal administration of mesenchymal stem cells is safe and feasible. According to Dr. Park, "These findings strongly suggest that phase II clinical trials are warranted to test the efficacy of mesencymal stem cell transplantation, which could lead to new therapies to prevent or cure BPD." Dr. Park and colleagues are currently conducting a long-term safety and follow-up study of these nine preterm infants ClinicalTrials.gov: NCT01632475).

Source: Eurekalert

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
* Your comment can be maximum of 2500 characters
Notify me when reply is posted
I agree to the terms and conditions

Related Links

More News on:

Stem Cells - Cord Blood Stem Cells - Fundamentals Parkinsons Disease Surgical Treatment Genetics and Stem Cells Sarcoidosis / Besnier - Boeck disease Asbestosis Pneumoconiosis Silicosis Bone Marrow Transplantation Tissue Engineering and Regenerative Medicine 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.


Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive