Low Levels of Antibodies Against Donated Organs Increases Risk of Organ Rejection Among Kidney Transplant Recipients

A new study published in the Journal of American Society of Nephrology reveals that the risk of organ rejection and kidney failure is high among kidney transplant recipients who have low levels of preformed antibodies directed against the donated organs.

The findings could help clinicians provide better donor-recipient matches and tailor recipients'' immunosuppressive therapy after transplantation.

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Transplant recipients who have had previous transplants, blood transfusions, and other sensitizing events often have antibodies directed against a particular donor''s kidney. These antibodies can increase the risk of organ rejection and kidney failure. But at what level do these antibodies put recipients at increased risk? Some newer tests, called solid phase assays, can detect them at much lower blood concentrations than traditional tests.

To investigate, Sumit Mohan, MD, Amudha Palanisamy, MD (Columbia University Medical Center) and their colleagues pored through the medical literature to find studies that looked at the health outcomes of kidney transplant recipients with such preformed donor-specific antibodies. Their search identified seven studies that included 1,119 patients.

Together, the results of these studies suggest that the detection of donor-specific antibodies by newer tests, despite negative results from older tests, nearly doubles the risk for antibody-mediated rejection and increases the risk of kidney failure by 76%. (The absolute risk of failure in the first year in the United States is currently about 8.2% for first-time recipients and about 10.7% for repeat transplant recipients.)

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"Our study quantifies the level of risk associated with antibodies detected at the time of transplantation, helping clinicians better understand the prognosis and the risk of failure, thereby allowing for appropriate tailoring of immunosuppressive therapy," said Dr. Mohan. It also suggests that donor selection processes should take into consideration the presence of antibodies in the recipient, as identified by newer, more sensitive tests.

Study co-authors include Demetra Tsapepas, PharmD, Bekir Tanriover, MD, R. John Crew, MD, Geoffrey Dube, MD, Lloyd E Ratner, MD, David Cohen, MD, and Jai Radhakrishnan, MD.

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Disclosures: The authors reported no financial disclosures.

The article, entitled "Donor-Specific Antibodies Adversely Impact Kidney Allograft Outcomes," will appear online at http://jasn.asnjournals.org/ on November 15, 2012, doi: 10.1681/2012070664.

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