Medindia

X

Low-calorie Diets and Healthy Ageing - How are They Related?

by Himabindu Venkatakrishnan on  March 2, 2015 at 4:35 PM Diet & Nutrition News   - G J E 4
Beneficial effects of low-calorie diets on healthy ageing has been highlighted in a new study. Targeting mechanisms in the central nervous system sense energy generated by nutrients.
 Low-calorie Diets and Healthy Ageing - How are They Related?
Low-calorie Diets and Healthy Ageing - How are They Related?
Advertisement

The study conducted at Harvard T.H. Chan School of Public Health suggested that Targeting mechanisms in the central nervous system that sense energy generated by nutrients might yield the beneficial effects of low-calorie diets on healthy aging without the need to alter food intake.

Advertisement
The study focused on a molecule called "AMP-activated protein kinase," or AMPK, which acts as a molecular fuel gauge to detect energy levels. It's been known that AMPK plays important roles in all cell types, but researchers didn't understand which of these activities were most critical to regulating longevity.

The researchers found that AMPK inhibited the activity of a protein called CRTC-1 in neurons. This process, in turn, controlled the behavior of mitochondria the primary energy-producing organelles in cells throughout the organism, by altering production of a neurotransmitter. The researchers were struck by the fact that altering the AMPK pathway in just a limited set of neurons was sufficient to override its effects on metabolism and longevity in other tissues. Aging was influenced more by what the animals perceived they were eating than what they actually ate.

The study suggested that manipulating this energy-sensing pathway can cause organisms to perceive their cells to be in a low-energy state, even if they are eating normally and energy levels are high. Drugs targeting the cells' energy-sensors in this way could potentially address age-related diseases, including cancer and neurodegeneration, and may offer an alternative to caloric restriction.

The study is published in the journal Cell.

Source: ANI
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All