Link Between Zinc Transport and Diabetes Identified

by Sheela Philomena on  September 25, 2013 at 11:19 AM Diabetes News
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People with a mutation in SLC30A8 - the gene encoding a zinc transporter have a higher risk of developing type 2 diabetes, says study. Insulin granules that are released from pancreatic β cells contain high levels of zinc; however, it is not clear why individuals with mutations in the SLC30A8 zinc transporter gene are predisposed to type 2 diabetes.
 Link Between Zinc Transport and Diabetes Identified
Link Between Zinc Transport and Diabetes Identified

In this issue of the Journal of Clinical Investigation, Yoshio Fujitani and colleagues at Juntendo University investigated the role of zinc transport by SLC30A8 in β cells. They found that this zinc transporter is required for insulin clearance by the liver and secreted zinc signals to β cells to stop releasing insulin. In the accompanying commentary, Alan Attie and colleagues at the University of Wisconsin-Madison discuss the dynamic regulatory role of zinc in insulin regulation.

Source: Eurekalert

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