Link Between Tanning Gene and High Testicular Cancer Risk Identified

by Sheela Philomena on  October 19, 2013 at 2:12 PM Cancer News
RSS Email Print This Page Comment bookmark
Font : A-A+

Skin tanning gene has been linked to increased risk for testicular cancer in white men.
 Link Between Tanning Gene and High Testicular Cancer Risk Identified
Link Between Tanning Gene and High Testicular Cancer Risk Identified

Scientists from the U.S. National Institutes of Health and the University of Oxford in England found that almost 80 percent of white men carry a variant form of this gene, which increased risk of testicular cancer up to threefold in the study.

The team suspected that variations in a gene pathway controlled by the tumor suppressor gene p53 could have both positive and negative effects on human health.

Douglas Bell, Ph.D., author on the paper and researcher at the National Institute of Environmental Health Sciences (NIEHS), part of NIH, said that gene variations occur naturally, and may become common in a population if they convey a health benefit.

Bell asserted that it appears that this particular variant could help protect light-skinned individuals from UV skin damage, like burning or cancer, by promoting the tanning process, but it permits testicular stem cells to grow in the presence of DNA damage, when they are supposed to stop growing.

Bell explained that p53 stimulates skin tanning when ultraviolet light activates it in the skin. It then must bind a specific sequence of DNA located in a gene called the KIT ligand oncogene (KITLG), which stimulates melanocyte production, causing the skin to tan.

The research has been published online in the journal Cell.

Source: ANI

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

Related Links

More News on:

DNA Finger Printing Cancer and Homeopathy Cancer Facts Cancer Tattoos A Body Art Testicular Cancer Testicular Self-Examination Weaver Syndrome Common Lifestyle Habits that Cause Diseases Health Benefits of Dandelion Plant 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive

Loading...