Link Between Leukemia and Down Syndrome

by Bidita Debnath on  August 8, 2014 at 11:52 PM Research News
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Children affected by trisomy 21 or Down syndrome are 50 to 500 times more likely to develop leukemia than other kids.
 Link Between Leukemia and Down Syndrome
Link Between Leukemia and Down Syndrome

A group of geneticists working in the Faculty of Medicine at the University of Geneva (UNIGE) focused for many years on the genetic characteristics of Down syndrome. They have sequenced the exome, a specific part of our genome, in a cohort of patients affected both by Down Syndrome and Acute Lymphoblastic Leukaemia (DS-ALL), a type of cancer relative to the cells of the immune system in the bone marrow.

They were able to sketch an outline of the "genetic identity card" of this disease. They found that RAS, an important oncogene in many cancers, is involved in the tumorigenesis of one third of DS-ALL cases. This work is being published in the latest issue of the journal Nature Communications.

Source: Eurekalert

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