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Link Between Cellular Metabolism and Anxiety Disorders

by Sheela Philomena on  May 18, 2012 at 11:53 AM Mental Health News   - G J E 4
A recent study provides a functional link between Glyoxylase 1 (GLO1) activity and anxiety disorders.

The normal role of GLO1 is to degrade cytotoxic byproducts of glycolysis, a function which has no obvious connection to anxiety.
 Link Between Cellular Metabolism and Anxiety Disorders
Link Between Cellular Metabolism and Anxiety Disorders
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Margaret Distler and colleagues at the University of Chicago asked whether the primary substrate of GLO1, methylglyoxal, might have undocumented neurological effects. Using a mouse model, they demonstrated that methylglyoxal stimulates robust activity from GABAA receptors, which are neuron receptors that respond to neurotransmitters.

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The team also showed that the inhibition of GLO1 in mice reduced anxious behavior, suggesting GLO1 as a potential novel therapeutic target in humans. These findings have important clinical implications not only for anxiety disorders, but also for other central nervous system diseases having proposed associations with the gene encoding GLO1, including autism, affective disorders, and schizophrenia.

Source: Eurekalert
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