Immune system ages faster in Mars owing to low gravity conditions. A new study found that spaceflight may be associated with a process of accelerated aging of the immune system.
Specifically, researchers found that mice in low gravity conditions experience changes in B lymphocyte production in their bone marrow similar to those observed in elderly mice living in Earth conditions.
Jean-Pol Frippiat at Lorraine University in Vandoeuvre-les-Nancy, France said that the study shows that a model of spaceflight conditions could not only be used to test the efficacy of molecules to improve immune responses following a spaceflight in astronauts, but also in the elderly and bed-ridden populations on Earth. This model could also help understanding the aging of the immune system called immunoscenescence.
Frippiat and colleagues used a ground-based model called hindlimb unloading (or HU), that simulates some of the effects of spaceflight on mice. They analyzed both bone parameters and the frequency of cells that will give birth to B lymphocytes in the bone marrow of young mice, old mice and mice subjected during three weeks to hindlimb unloading. Comparison of these data revealed that bone changes and changes in the production of B lymphocytes in the bone marrow of HU mice were very similar to those observed in old mice. This study shows that HU could be interesting to improve understanding of the relationship between bone remodeling and B cell production in the bones, both in the context of spaceflight and normal aging on Earth. This model could therefore be used to test and/or develop molecules and compounds to improve immune responses following spaceflight in astronauts or in elderly and bed-ridden populations.
The research is published online in The FASEB Journal.