Research has indicated that suspicion resides in two distinct regions of the brain: the amygdala and the parahippocampal gyrus.
This is the conclusion of a new study by scientists at the Virginia Tech Carilion Research Institute including one of an Indian origin.
"We wondered how individuals assess the credibility of other people in simple social interactions," said Read Montague, director of the Human Neuroimaging Laboratory and the Computational Psychiatry Unit at the Virginia Tech Carilion Research Institute, who led the study.
"We found a strong correlation between the amygdala and a baseline level of distrust, which may be based on a person's beliefs about the trustworthiness of other people in general, his or her emotional state, and the situation at hand. What surprised us, though, is that when other people's behaviour aroused suspicion, the parahippocampal gyrus lit up, acting like an inborn lie detector," he explained.
The scientists used functional magnetic resonance imaging, or fMRI, to study the neural basis of suspicion. Seventy-six pairs of players, each with a buyer and a seller, competed in 60 rounds of a simple bargaining game while having their brains scanned.
At the beginning of each round, the buyer would learn the value of a hypothetical widget and suggest a price to the seller. The seller would then set the price. If the seller's price fell below the widget's given value, the trade would go through, with the seller receiving the selling price and the buyer receiving any difference between the selling price and the actual value. If the seller's price exceeded the value, though, the trade would not execute, and neither party would receive cash.
The researchers found that buyers fell into three strategic categories: 42 percent were incrementalists, who were relatively honest about the widget's value; 37 percent were conservatives, who adopted the strategy of withholding information; and 21 percent were strategists, who were actively deceptive, mimicking incrementalist behavior by sending high suggestions during low-value trials and then reaping greater benefits by sending low suggestions during high-value trials.
The sellers had a monetary incentive to read the buyers' strategic profiles correctly, yet they received no feedback about the accuracy of the information they were receiving, so they could not confirm any suspicions about patterns of behaviour. Without feedback, the sellers were forced to decide whether they should trust the buyers based on the pricing suggestions alone.
"The more uncertain a seller was about a buyer's credibility," Montague said, "the more active his or her parahippocampal gyrus became."
The team believe a person's baseline suspicion may have important consequences for his or her financial success.
"People with a high baseline suspicion were often interacting with fairly trustworthy buyers, so in ignoring the information those buyers provided, they were giving up potential profits," said Meghana Bhatt, PhD, an assistant research professor at the Beckman Research Institute of the City of Hope Hospital in Duarte, Calif. and the first author on the research paper.
"The ability to recognize credible information in a competitive environment can be just as important as detecting untrustworthy behaviour," she added.
The findings may also have implications for such psychiatric conditions as paranoia and anxiety disorders, said Montague.
"The fact that increased amygdala activation corresponds to an inability to detect trustworthy behavior may provide insight into the social interactions of people with anxiety disorders, who often have increased activity in this area of the brain," he said.
The research recently appeared in the early online edition of the Proceedings of the National Academy of Sciences (PNAS).