Leprosy Drug Holds Promise for Autoimmune Diseases Also

by Tanya on  February 02, 2009 at 10:35 AM Drug News
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However, when they pre-treated the immune cells with clofazimine, the calcium rush was much less and it didn’t hang around as long. 

The study showed that clofazimine press down the presence of free calcium in immune cells by disrupting a potassium channel. 

Liu said: "This let us conclude that clofazimine was blocking the calcium influx into the immune cells. 

"Without enough calcium getting inside a cell, the signalling pathway that turns on the immune response was short-circuited."  



The combined effect is to shut down a signaling pathway involved in autoimmune disease.  



The study is reported in Public Library of Science (PLoS One).

Source-ANI
TAN/L
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