Work is being undertaken on the development of substances that can prevent parasites, bacteria and fungi from producing essential proteins. This research that could, in the long term, lead to new drugs for several major diseases is being taken up by researchers at the University of Gothenburg, Sweden.
The World Health Organization (WHO) has announced that aminoacyl-tRNA synthetases - a type of enzyme - are important targets for the development of new drugs for several major diseases such as cancer, various parasitic diseases and bacterial and fungal infections.These enzymes are involved in the production of proteins (protein synthesis) in all organisms. Their job is to ensure that the right amino acid is linked to the growing protein chain. These enzymes are essential for all living organisms.
Challenging research field
Researchers at the University of Gothenburg are currently undertaking basic research in this challenging field. The aim is to prevent the enzyme from producing proteins in bacteria, parasites or fungi, without stopping it from functioning in the human body.
"We're collaborating with researchers in several countries," says researcher Itedale Namro Redwan. "Our role has been to design and to synthesise substances that can be used for the development of drugs against parasitic diseases."
Looking for an effective substance
The enzymes' job of ensuring that the right amino acid is linked to the growing protein chain works in the same way in all types of cell, be they human or parasitic.
"The real challenge is identifying substances that act on enzymes in the parasite alone, without affecting the human enzymes at the same time," says Itedale Namro Redwan, who is making substances that can prevent bacterial and parasitic enzymes from functioning, but do not affect human enzymes. If this proves possible, it will help in the development of drugs for several major diseases.