Kidney Disease Drug Does Not Help Transplant Recipients

by VR Sreeraman on  January 11, 2013 at 6:17 PM Drug News
RSS Email Print This Page Comment
Font : A-A+

A drug that helps to treat chronic kidney disease does not offer the same benefit for those who had undergone kidney transplantation, according to a study.
 Kidney Disease Drug Does Not Help Transplant Recipients
Kidney Disease Drug Does Not Help Transplant Recipients

Immunosuppressants help prolong the function of transplanted organs, but therapies that target non-immunological damage to these organs-such as elevated blood pressure and tissue scarring (or fibrosis)-have not been studied.

Angiotensin II blockade, which causes blood vessels to dilate, can slow the progression of kidney disease in individuals without kidney transplants. Hassan Ibrahim, MD (University of Minnesota) and his colleagues set out to test the strategy in transplant recipients. "To our knowledge this is the first randomized placebo-controlled trial of angiotensin II blockade in these patients," said Dr. Ibrahim.

The investigators assigned 153 kidney transplant recipients to receive the angiotensin II receptor blocker losartan or placebo within three months of transplantation, continuing treatment for five years.

"Contrary to what has been observed in native kidney disease, angiotensin II blockade did not demonstrate a statistically significant benefit in lessening fibrosis or terminal kidney failure from severe fibrosis. Nevertheless, angiotensin II blockade was safe and well-tolerated," said Dr. Ibrahim. He noted that a similar trial is ongoing in Canada.

The findings provide valuable information for future studies of non-immunological therapies for kidney transplant recipients.

Source: Newswise

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

Related Links

More News on:

Drug Toxicity Urinary Stones In Children Vesico-Ureteric Reflux Causing UTI in Children Hydronephrosis / Antenatal Counseling Signature Drug Toxicity Kidney Disease Kidney Kidney Health Stones in Urinary Tract Renal Tubular Acidosis 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Advertisement
Advertisement

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive