Keyhole Surgery Shows Better Outcomes For Ruptured Aneurysm

Highlights

Keyhole surgery to repair endovascular aneurysm does not reduce the high death rate up to three months after surgery compared with open repair.
Duration of hospital stay was less and the cost of the treatment was lower in those who underwent keyhole surgery.
Average quality of life was higher in the keyhole group in the first year, but by three years was similar across the groups.

Keyhole surgery to repair ruptured aortic aneurysm is cost effective and has better outcomes. A randomised trial comparing the use of keyhole (endovascular) aneurysm repair versus traditional open surgery suggests that keyhole surgery should be adopted more widely.

Abdominal aortic aneurysm is a swelling of the aorta - the main blood vessel that leads away from the heart, down through the abdomen to the rest of the body. If the artery wall ruptures, the risk of death is high, and emergency surgery is needed.

Abdominal Aortic Aneurysm - Causes, Types, Symptoms, Complications, Diagnosis & Treatment
The dilatation and localized bulging of a part of aorta in the abdominal part of patient’s body owing to weakness of its walls is called abdominal aortic aneurysm.

‘Early higher average quality of life, coupled with the lower mortality at three years, led to a gain in average quality adjusted life years in those who underwent keyhole surgery.’

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Recently, three European randomised trials showed that keyhole repair does not reduce the high death rate up to three months after surgery compared with open repair. However, mid-term outcomes (three months to three years) of keyhole repair are still uncertain.

Mid-term Outcomes Of Keyhole Surgery

So an international research team set out to assess three-year clinical outcomes and cost-effectiveness of a strategy of keyhole repair (whenever the shape of the aorta allows this) versus open repair for patients with suspected ruptured abdominal aortic aneurysm who were part of the IMPROVE trial.

Aortic Dissection | Aortic Aneurysm - Types, Causes, Symptoms, Diagnosis, Treatment
Aortic dissection refers to a serious condition where there is a tear in the wall of a major artery leading to blood flow within the layers of the aorta.

The trial involved 613 patients from 30 vascular centres (29 in the UK, one in Canada) with a clinical diagnosis of the ruptured aneurysm, of whom 316 were randomised to a strategy of keyhole repair and 297 to open repair.

The findings include:

For 4.9 years, deaths were similar in both groups three months after surgery.
At three years, there were fewer deaths in the keyhole group than in the open repair group, leading to lower mortality (48% vs 56%).
After seven years there was no clear difference between the groups.
The need for repeat surgery (reinterventions) related to an aneurysm occurred at a similar rate in both groups, with about 28% of each group needing at least one reintervention after three years.
Average quality of life was higher in the keyhole group in the first year, but by three years was similar across the groups.
This early higher average quality of life, coupled with the lower mortality at three years, led to a gain in average quality-adjusted life years or QALYs (a measure of healthy years lived) at three years in the keyhole versus the open repair group.
On average, the keyhole group also spent fewer days in the hospital (14.4 versus 20.5 in the open repair group) and had lower overall costs in the open repair group.

The researchers point to some study limitations, such as sample size and midterm data focusing on aneurysm-related events, which may have led to some bias.

Aneurysm - Types, Causes, Symptoms, Diagnosis, Treatment, Prevention
An aneurysm is an abnormal “ballooning” in blood vessels usually in the wall of arteries.

Nevertheless, they say compared with open repair, "an endovascular strategy for suspected ruptured abdominal aortic aneurysm was associated with a survival advantage, a gain in QALYs, similar levels of reintervention, and reduced costs, and this strategy was cost-effective."

"These findings support the increasing use of an endovascular strategy, with wider availability of emergency endovascular repair," they conclude.

Low-Calorie Diet Reduces the Risk of Abdominal Aortic Aneurysm
Abdominal aortic aneurysm is the enlargement of an artery in the abdomen. Following a low-calorie diet may reduce the risk of developing the fatal condition.

In a linked editorial, Martin Bj枚rck, Professor of Vascular Surgery at Uppsala University in Sweden, says these three-year results "will change clinical practice in favor of endovascular repair for patients with suspected ruptured abdominal aortic aneurysms (AAA)."

However, he points out that prevention is always better than cure - the most effective way to prevent ruptured AAA is to avoid smoking, he says, followed by early recognition and repair of aneurysms before rupture. There are still knowledge gaps to be dealt with in future studies, he concludes.

Reference

Martin Björck et al., Keyhole surgery more effective than open surgery for ruptured aneurysm. The BMJ (2017).

Source-Medindia