Scientists Find Method to Make Complex Anticancer Compound
At The Scripps Research Institute (TSRI), scientists have achieved the first efficient chemical synthesis of ingenol, a highly complex, plant-derived compound that has long been of interest
At The Scripps Research Institute (TSRI), scientists have achieved the first efficient chemical synthesis of ingenol, a highly complex, plant-derived compound that has long been of interest
‘Enhancing the anticancer effect inside the tumors using an epithelial junction opener increases the success rate in solid tumors, which are hard to treat.
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In the article "Epithelial Junction Opener Improves Oncolytic Adenovirus Therapy in Mouse Tumor Models," the researchers demonstrate that administering the JO protein together with an oncolytic adenovirus into the tumors of mice, or engineering the virus to produce and secrete the JO protein inside tumor cells, greatly enhances the antitumor effect compared to treatment with unmodified virus. This article is part of a Festschrift in honor of George Stamatoyannopoulous, MD, DrSci, Professor of Medicine and Genome Sciences, and Director, Markey Molecular Medicine Center, University of Washington, Seattle.
"Oncolytic adenoviruses are rapidly making a big impact in therapy for many different cancers," says Editor-in-Chief Terence R. Flotte, MD, Celia and Isaac Haidak Professor of Medical Education and Dean, Provost, and Executive Deputy Chancellor, University of Massachusetts Medical School, Worcester, MA. "The concept of enhancing the penetration of such viruses into tumors using an epithelial junction opener promises to improve the success rate of such therapies in bulkier solid tumors, which are often very hard to treat."
Anticancer Drug Restores Hearing in People With Neurofibromatosis
One in 25,000 people is born with neurofibromatosis type 2, a hereditary tumor syndrome in which virtually everyone progresses to deafness because of vestibular schwannomas.
One in 25,000 people is born with neurofibromatosis type 2, a hereditary tumor syndrome in which virtually everyone progresses to deafness because of vestibular schwannomas.
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Target of Anticancer Drugs Have Broader Functions
Histone deacetylases (HDACs) are the drugs that inhibit the activity of enzymes. They are being widely developed for treating cancer and other diseases, with two already on the market.
Histone deacetylases (HDACs) are the drugs that inhibit the activity of enzymes. They are being widely developed for treating cancer and other diseases, with two already on the market.
Anticancer Drug Mechanism Understood Better
The subtle effect that prescription drug Taxol has inside cells, which makes it one of the most widely used anticancer drugs in the world has now been understood by a team of researchers
The subtle effect that prescription drug Taxol has inside cells, which makes it one of the most widely used anticancer drugs in the world has now been understood by a team of researchers
