Is There a Link Between Low Birth Weight Among IVF Children and Infertility Treatments?

Children conceived through medically assisted reproduction are more likely to be born premature and are at greater risk of being born small than naturally conceived babies, according to new research published today by the UCL Centre for Longitudinal Studies in collaboration with the University of Utah.

Researchers analyzed data on 248,000 babies born in Utah between 2009-2017 whose anonymized birth records are part of the Utah Population Database. The findings are published in the journal Obstetrics and Gynecology.

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‘Family circumstances and unobserved parental characteristics, such as genetic traits, are important factors that explain the association between medically assisted reproduction and children’s adverse birth outcomes.’

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They examined information to look at the effects of different types of infertility treatments on pregnancy terms and children’s birth weight.

They also analyzed rich data on mothers’ health, including pre-pregnancy body mass index (BMI) and blood pressure, parents’ age, and education level, before examining information on infant birth order and multiple births.

Around 5% of infants were conceived using MAR, with fertility-enhancing drugs used by 60%, assisted reproduction (including IVF) by 26%, and artificial insemination by 14%.

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The study found that children who were conceived through MAR were 10% more likely to be born premature and had 9% greater odds of being born small than naturally conceived infants.

More invasive treatments – such as assisted reproduction and artificial insemination - were more strongly associated with adverse birth outcomes, whereas infants conceived using fertility-enhancing drugs were more similar to those who were naturally conceived.

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“This study was possible because of the Utah Population Database and the secure access it provides to anonymized data. This has allowed us to study births throughout the state to understand possible effects on newborns associated with mothers who conceived naturally or through medically assisted methods,” said co-author Ken Smith, Ph.D., distinguished professor of Family Studies and Population Science at the University of Utah.

Researchers then considered mothers’ health, parents’ socioeconomic background, and infants’ birth characteristics, the differences in adverse birth outcomes were significantly reduced for all types of treatments.

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Then they focused on a subgroup of mothers who had given birth to both MAR and naturally conceived children over the eight years.

After accounting for the mother’s age at birth, pre-pregnancy BMI, and infants’ birth characteristics, the differences in pregnancy term and children’s birth weight between siblings disappeared.

They also found limited evidence of the effects of medically assisted reproduction treatments on pregnancy term and birth weight through comparing siblings’ birth outcomes, which is in line with existing studies from the Nordic countries.

Obtaining similar results in highly diverse contexts in terms of demographics, fertility rates, and access to medically assisted reproduction treatments, strengthens the argument that adverse birth outcomes among medically assisted reproduction conceived infants are unlikely to be driven by the reproductive technology itself.

Source-Medindia