Intestinal Inflammation and Carcinogenesis may be Abetted by Bacterial Imbalance

Previous research has indicated that instability in the composition of gut bacterial communities called dysbiosis can cause common human intestinal disorders, including inflammatory bowel disease and colorectal cancer.

However, it is unclear if dysbiosis can instigate disease or if it is a consequence of the underlying disorder.

Legionnaires’ disease - Symptoms - Causes - Risk Factors - Diagnosis - Treatment
Legionnaires’ disease is a severe form of pneumonia caused by a type of bacteria. The infection is likely to spread when people inhale tiny water droplets containing the bacteria.

In this issue of the Journal of Clinical Investigation, researchers led by Mathias Chamaillard at the University Lille Nord de France in Lille, France, examined intestinal inflammation and tumorigenesis in a mouse model of dysbiosis. Dysbiosis enhanced intestinal inflammation and increased the risk for inflammation-associated colon cancer. Treatment with antibiotics or transplantation of fecal material from normal mice reduced disease risk and instigated long-term, beneficial alterations in intestinal bacteria. Conversely, transplantation of normal mice with dysbiotic fecal material increased intestinal inflammation and enhanced the risk of inflammation-associated colon cancer. These results demonstrate that gut bacterial communities play an integral role in protecting against intestinal inflammation and associated tumorigenesis.

Source-Eurekalert

About Mosquito Diseases
Mosquito-borne diseases, like malaria, filaria, dengue, etc are common in places conducive of mosquito breeding. Swamps, ponds and stagnated drainage provide optimal breeding ground for mosquitoes.

About Bacterial Vaginosis
Bacterial vaginosis (BV) is a disorder characterized by an offensive vaginal discharge & it is most common among women of childbearing age.