Even a few minutes of severe brain ischemia may cause massive neuronal death. Lobachevsky University researchers are working to explore the mechanisms of adaptation of the nervous system to ischemic damage. Scientists say that under certain conditions, the brain's protective forces can be activated, even in some severe cases.
‘The study of the nervous system's adaptive and regenerative properties will allow the development of a new therapeutic strategy for protecting the brain from traumatic and ischemic damage.’
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According to Maria Vedunova, Director of the Institute of Biology and Biomedicine at Lobachevsky University, a large number of stressors affect the body by depleting its internal reserves and, as a consequence, leading to a number of diseases. "The effect of stress on the nervous system and the brain is especially damaging. Everything that we associate with the personality, self-consciousness, all our feelings and thoughts, decisions and experiences - all this is the result of the brain function. Therefore, scientists and medical practitioners face a global challenge - to find an effective way to protect nervous system cells and restore lost brain functions after damage. By solving this problem, it will be possible to change the quality of life of those who have suffered a stroke, severe trauma or surgery," notes Maria Vedunova.
UNN scientists are currently involved in the study of the role of internal adaptation systems of the central nervous system.
"We are developing ways to repair brain damage. To understand the mechanisms of ischemia and effectively combat this disease, each of its key links has to be examined separately. For this purpose, scientists create special model conditions to study the primary cultures of the cells from different brain sections (the "brain in vitro") rather than the whole brain. Thus, one can trace the processes taking place at the neural network level. Why is it so important? In fact, the brain functions are performed not by single neurons, but by their groups, neural networks.
It is at the level of the neural network (the minimal structural and functional unit of the nervous system) that information is transferred, processed and stored, and complex cognitive reactions occur. In a cell culture, one can see how the neural network is formed, how an electrical impulse is generated, and how it is distributed and transmitted over the network, how the entire functional ensemble reacts to ischemic damage. Researchers around the world hope that the understanding of the way neural networks function in the normal state and under the effect of stressors will open up prospects for the development of effective therapeutic strategies.
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UNN scientists have developed some methods for modeling different phases of ischemia and studied the features of the neural network operation under such effects. When modeling ischemic damage, very large numbers of neurons die, but their death does not occur simultaneously. Ischemic factors trigger pathological reactions within active neurons that lead to cell death within 3-6 days after an episode of ischemia.
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These studies are of great fundamental importance. In the near future, the study of the nervous system's adaptive and regenerative properties will allow the development of a new therapeutic strategy for protecting the brain from traumatic and ischemic damage, thus contributing to the improvement of life quality and reducing the risk of severe disability among the working-age population.
Source-Eurekalert