Inhibiting Neural Apoptosis With Recombinant Adenovirus-Mediated 3β-Hydroxysteroid-Δ24 Reductase

by Himabindu Venkatakrishnan on  May 13, 2014 at 9:40 AM Research News
RSS Email Print This Page Comment
Localizing of the multifunctional enzyme 3β-Hydroxysteroid-Δ24 reductase (DHCR24) to the endoplasmic reticulum has neuroprotective and cholesterol-synthesizing abilities. DHCR24 overexpression confers neuroprotection against apoptosis caused by amyloid β deposition.
 Inhibiting Neural Apoptosis With Recombinant Adenovirus-Mediated 3β-Hydroxysteroid-Δ24 Reductase
Inhibiting Neural Apoptosis With Recombinant Adenovirus-Mediated 3β-Hydroxysteroid-Δ24 Reductase
Advertisement

Dr. Xiuli Lu and colleagues from Liaoning University in China constructed two recombinant adenoviruses (Ad-rSYN1-DHCR24-myc and Ad-hSYN1-DHCR24-myc) that drive DHCR24 expression specifically in neuronal cells. They also found that adenovirus transfection inhibits apoptosis through scavenging excess reactive oxygen species. In summary, these researchers have for the first time successfully constructed an adenovirus that induces DHCR24 specifically in neuronal cells. These findings published in the Neural Regeneration Research (Vol. 9, No. 5, 2014) will lay the foundation for further studies on DHCR24 gene therapy and neuronal functional research in animal models.

Advertisement
Source: Eurekalert
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
* Your comment can be maximum of 2500 characters
Notify me when reply is posted
I agree to the terms and conditions
Advertisement

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Advertisement

Advertisement
Advertisement

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive