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Infection-Fighting B Cells Go With the Blood Flow

by Bidita Debnath on  November 17, 2014 at 10:16 PM Research News   - G J E 4
B cells can afford to be lazy when it comes to leaving the bone marrow.
 Infection-Fighting B Cells Go With the Blood Flow
Infection-Fighting B Cells Go With the Blood Flow
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João Pereira and colleagues at Yale University School of Medicine show that B cells actively migrate around the bone marrow with the help of CXCR4 and an integrin called VCAM-1. Without CXCR4, the cells slowed down and many stopped moving entirely, in part due to decreased expression of VCAM-1. For those cells near exit sites, decreased CXCR4 and VCAM-1 allowed them to be passively swept out of the bone marrow with the blood flow.

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Why immune cells use different exit strategies in different organs is not completely clear. But the authors suggest that the go-with-the-flow strategy of the bone marrow may be due to its role in the production of red blood cells, which do not express molecules required for active crawling.

Source: Eurekalert
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