Inexact Test Results Probably Fostered by All-They-Can-Eat Diet For Lab Mice And Rats

by Nancy Needhima on  July 23, 2012 at 12:00 AM Research News
RSS Email Print This Page Comment bookmark
Font : A-A+

The prevalent practice of permitting lab rats and mice to eat as much as they want could affect the result of experiments in which scientists employ these 'test-tubes-on-four-feet' to test new drugs and other substances for toxicity and other effects. That's the conclusion of a new analysis published in ACS' journal Chemical Research in Toxicology.
Inexact Test Results Probably Fostered by All-They-Can-Eat Diet For Lab Mice And Rats
Inexact Test Results Probably Fostered by All-They-Can-Eat Diet For Lab Mice And Rats

Laboratory mice and rats serve as stand-ins for people for research that cannot be done on humans. In the article, Gale Carey and Lisa Merrill point out that the millions of lab rodents used in laboratory studies each year have a nutritional status that is different from other test animals. While other test animals are fed meals, rodents have round-the-clock access to food. And eat they do, gaining more weight and more body fat than meal-fed rodents. The authors cite other research indicating that lab rodents with free access to food tend to develop abnormally high blood fat levels, high cholesterol, nerve and heart damage, cancer and other disorders.

Their analysis of 54 studies concluded that having free access to food is likely to affect the results of tests for the toxicity and cancer-causing effects of new drugs and other substances in rodents, and could be the reason why such studies have been varying so much in recent years. "Therefore, it is crucial that feeding regimen be carefully considered in designing toxicology experiments," say the authors.

Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

Related Links

More News on:

Diet Pills Low Carbohydrate Diet Atkins Diet The Cabbage Diet South Beach Diet Negative Calorie Diet Bulimia Nervosa Why Do We Eat - Nutrition Facts Diet Lifestyle and Heart Disease Varicocele 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive

Loading...