Indian origin student, Kirtana Vallabhaneni named the UK's top young scientist for her research project aimed at identifying the harmful cells that cause pancreatic cancer.
The 17-year-old beat 360 other entrants at The Big Bang Fair at Birmingham's NEC on Friday to win the award.
She said she hoped her win could help "instil the same kind of passion I have for science in other young people".
The judging panel for the national award, open to 11 to 18-year-olds who completed a science, technology, engineering or maths project, included renowned space scientist Dr Maggie Aderin-Pocock, Nobel Prize winning biochemist Sir Tim Hunt, and the Science Museum's inventor in residence Mark Champkins.
Vallabhaneni, who was part of the project team working to isolate cells in the pancreas that can be targeted with chemotherapy, said she was "so happy" with the win.
"Everything that I've worked for over the last year has come together," the BBC quoted her as saying.
"The fact four finalists were female shows that there are strong opportunities for women in science and it proves they don't have to follow convention and stereotypes.
"I'm so passionate about what I do and I hope that with this success, I can instil the same kind of passion I have for science in other young people... If I can do it, they definitely can," she added.