Increased Fatty Acids Disrupt Insulin Secretion In Diabetic Patients

by Rukmani Krishna on  September 12, 2013 at 12:09 AM Diabetes News
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Increased levels of circulating glucose and fatty acids can be found in patients with type 2 diabetes, which in turn leads to disease complications. In healthy individuals, β cells within pancreatic islets release insulin in response to glucose and incretins, which are gastrointestinal hormones. Coordination between β cells is predicted to be important for insulin release.
 Increased Fatty Acids Disrupt Insulin Secretion In Diabetic Patients
Increased Fatty Acids Disrupt Insulin Secretion In Diabetic Patients

In this issue of the Journal of Clinical Investigation, David Hodson and colleagues at Imperial College London demonstrate that β cell-β cell interactions are important for insulin secretion in human islets and that these interactions are regulated by incretins. The authors found that increased fatty acid levels suppressed incretin-associated insulin release. These findings indicate that therapies aimed at maintaining β cell connectivity may be useful for restoring glucose balance in type 2 diabetes.

Source: Eurekalert

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