In Mice Lifespan-extending Drug Reverses Age-related Heart Disease

Elderly mice suffering from age-related heart disease had a significant improvement in cardiac function after being treated with the FDA-approved drug rapamycin for just three months, according to a study.

The research, led by a team of scientists at the Buck Institute for Research on Aging, showed how rapamycin impacts mammalian tissues, providing functional insights and possible benefits for a drug that has been shown to extend the lifespan of mice as much as 14 percent.

Researchers at the Mayo Clinic are currently recruiting seniors with cardiac artery disease for a clinical trial involving low dose treatment with rapamycin.

Rapamycin is an immunosuppressant drug that can be used to help prevent organ rejection after transplantation. It is also included in treatment regimens for some cancers.

In this study, rapamycin was added to the diets of mice that were 24 months old - the human equivalent of 70 to 75 years of age. Similar to humans, the aged mice exhibited enlarged hearts, a general thickening of the heart wall and a reduced efficiency in the hearts ability to pump blood.

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The mice were examined with ultrasound echocardiography before and after the three-month treatment period - using metrics closely paralleling those used in humans.

Buck Institute faculty Simon Melov, PhD, the senior author of the study, said age-related cardiac dysfunction was either slowed or reversed in the treated mice.

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"When we measured the efficiency of how the heart pumps blood, the treated mice showed a remarkable improvement from where they started. In contrast, the untreated mice saw a general decline in pumping efficiency at the end of the same three month period," he said.

"This study provides the first evidence that age-related heart dysfunction can be improved even in late life via appropriate drug treatment," added Melov, who said the treated mice saw a reduction in heart size, reduced stress signaling in heart tissues and a reduction in inflammation.

Melov said in this study, the drug had only mild transient metabolic effects. Future studies will focus on better understanding the molecular targets that drive age-related heart dysfunction, and why rapamycin treatment is so beneficial to the aging hearts.

The study results will appear online in Aging Cell.

Source-ANI