Male Factors could be the Cause of Infertility even if Semen Parameters are Normal

Giving hope to couples having difficulty conceiving, a team of scientists has developed the first diagnostic test for sperm RNA based on next-generation sequencing.

The test may help determine the best infertility treatment for childless couples.

Identification of Enzymes In Sperm-Egg Fusion May Favor Contraception Methods
Getting at the molecular components of the fertilization can be applied to block the protein’s interactions and prevent pregnancy.

"Upon validation, this discovery may help to identify those couples who may benefit from assisted reproductive technologies and those couples who may be successful with minimal intervention," said Stephen Krawetz from Washington State University.

Published in Science Translational Medicine, the study spells out how male factors could be the cause of infertility in couples even when tested semen parameters are normal.

The use of next-generation sequencing of spermatozoal ribonucleic acids, or RNAs, can provide an objective measure of the paternal contribution.

Couples Favor Same Sperm or Egg Donor for All Their Conceptions
While sperm donation imply the genetic detachment of the child from one of its parents, couples seem determined to ensure genetic bonds between their children.

This may also help guide couples to the most effective method in overcoming infertility.

It is our hope that by identifying the extent of the father’s contribution, the responsibility for setting the course for the birth of a healthy child can now be more equally shared, Krawetz said.

Fox13 Gene - the 'Genetic Switch' Determines Whether Germ Cells Become Sperm Or Eggs
The gene in Japanese rice fish, expressed in the germ cells, provides a molecular cue that prevents the start of sperm formation.

These findings will lead to dramatic changes in the way infertile couples are treated and helping them in achieving pregnancy.

The semen parameters’ evaluation may be useful in the diagnosis of obvious cases of male infertility, but no single parameter or set of parameters serve as highly predictive of male fertility.

French Lab Claims Breakthrough With the World's First Lab-Grown Human Sperm Cells
Research paves way for innovative therapies to preserve and restore male fertility, a major issue with global impact as numbers of spermatozoa have declined.

The diagnostic potential of next-generation sequencing of spermatozoal RNA indicates this method is "better suited to the task" of analyzing the male’s role in infertility.

This is also a step toward personalized precision reproductive medicine that may help guide the couple to their successful treatment.

While the test is experimental, it has the potential for cost savings for both the patients and the health care system.

Source-IANS