Data on an immune response in prostate cancer tumors, effects of paternal age on stimulated insemination live birth rates, issues of sexual function after cystectomy and a comparison of modalities for the treatment of benign prostatic hyperplasia (BPH) are amongst the studies that will be presented by researchers at the Icahn School of Medicine at Mount Sinai at the 2014 American Urological Association (AUA) annual meeting May 17-19, 2014 in Orlando, FL.
Meeting attendees will be able to view a live 3-dimensional video feed of a robotic prostatectomy performed by Ashutosh K. Tewari, MBBS, MCh, Chairman, Milton and Carroll Petrie Department of Urology, Icahn School of Medicine at Mount Sinai, who has performed over 5,500 robotic prostatectomies and is one of the world's foremost researchers and surgeons in this field.
AdvertisementHighlights of Mount Sinai research at AUA:
- Sipuleucel-T-Induced Antigen Spread: Immune Response to Prostate-Specific Antigen Correlates with Improved Overall Survival Rates
"The study data demonstrated that a subset of patients (30%) vaccinated against one specific antigen, PAP, develop immune response to other antigens; this antigen spread is associated with a profound enhancement of survival. This study thus demonstrates some of the complexities of immunotherapy in patients and serves as a backdrop for further studies to enhance anticancer immune therapies," said Dr. Hall.
This multi-center study included collaboration with Johns Hopkins University School of Medicine, Baltimore, MD; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; University of California, San Francisco, CA; Indiana University Simon Cancer Center, Indianapolis, IN; and University of Washington School of Medicine, Seattle, WA. Grant funding for this study was provided by the Dendreon Corporation, Seattle, WA.
- Stimulated Intrauterine Insemination Live Birth Rates are Adversely Affected by Increasing Paternal Age
"This study the largest of its kind to date, clearly demonstrates that advanced paternal age negatively impacts fertility outcomes in couples undergoing the most common form of assisted reproductive technologies; stimulated intrauterine inseminations," said Dr. Bar-Chama. "This effect is important for us to discuss with the couples we care for and will enable us to better counsel patients undergoing this reproductive treatment."
Benign prostatic hyperplasia (BPH) is a non-cancerous increase in the size and number of cells that make up the prostate. There are several surgical modalities used at Mount Sinai in the treatment of BPH. Michael A. Palese, MD, Director of Minimally Invasive Surgery, Associate Professor, Urology, Icahn School of Medicine at Mount Sinai, will lead one of the first comparisons of all four minimally invasive modalities for the treatment of BPH at a single institution.
"Our findings will help us select the optimal treatment for each patient. This research will provide a standard of care for the surgical treatment of BPH," said Dr. Palese.
- Research on Addressing Needs of Patients Undergoing Cystectomy and Urinary Diversion
"Understanding the needs of our patients is pivotal to improving health outcomes and achieving patients' and families' satisfaction," said Mohamed.
A second study led by Nihal Mohamed, PhD, evaluates the impact of radical cystectomy on patients' quality of life, with a special focus on the sexual and urinary function. This research will help clinicians to better understand the emotional and psychosomatic aspects that influence patients' quality of life following radical cystectomy.
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