A study about how birth affects development of the immune system in newborn mouse pups may help researchers at Faculty of Health and Medical Sciences determine the difference of intestinal flora among children delivered by Caesarean section and natural birth
The study shows that pups delivered by Caesarean section had developed a lower number of cells that strengthen the immune system, says Camilla Hartmann Friis Hansen, Assistant Professor at the Department of Veterinary Disease Biology. The findings have recently been published in Journal of Immunology
Mother's bacteria may be important
Newborns delivered by natural birth are exposed to more bacteria from the mother than those delivered by Caesarean section. According to a research hypothesis called the hygiene hypothesis, the newborn baby's immune system in this way learns to distinguish between its own harmless molecules and foreign molecules. In the experiment, pups delivered by Caesarean section showed a lower number of cells of a type that plays an important role in preventing reactive immune cells from responding to molecules from the body itself, from the diet and from harmless intestinal bacteria. Autoimmune diseases such as type 1 diabetes, Chrohn's disease and allergy are precisely characterised by an over-reaction by the immune system.
The researchers then looked for signs of development of type 1 diabetes in pups delivered by Caesarean section, but found none. The next step is therefore to study whether the pups are predisposed to other autoimmune diseases and then to test the theses in clinical trials.
The experiments on mice may give us an idea of what would be interesting to study in more detail in clinical trials, so that in the long term, we may be able to develop methods for strengthening the immune system in newborns who are predisposed to autoimmune diseases, says Professor Axel Kornerup Hansen, Department of Veterinary Disease Biology.