X

Immune Drug Benefits Patients With Serious Kidney Disorder

by Sheela Philomena on  July 27, 2012 at 12:29 PM Drug News   - G J E 4
A -A +
A drug used to treat immune disorders helps patients with serious kidney disease, reveals study published in the Journal of the American Society of Nephrology. The findings could help people who are living with the condition, called idiopathic membranous nephropathy (IMN), avoid taking the potentially toxic medications that are currently prescribed to treat it.
 Immune Drug Benefits Patients With Serious Kidney Disorder
Immune Drug Benefits Patients With Serious Kidney Disorder

Standard therapy for IMN includes nonspecific immunosuppression with steroids and other agents that do not work in all patients and can cause serious complications. Because the drug rituximab specifically targets immune cells involved in the development and progression of IMN, Piero Ruggenenti, MD, Giuseppe Remuzzi, MD, FRCP (Mario Negri Institute for Pharmacological Research and Ospedali Riuniti, in Bergamo, Italy) and their colleagues tested its safety and effectiveness in 100 patients with IMN. The looked to see how many patients experienced complete or partial remission, based on the amount of protein excreted in the urine.

Among the major findings:
- Over an average of 29 months, 65 out of the 100 patients taking rituximab treatment experienced remission of their disease. Twenty-seven of these patients achieved complete remission.
- All patients with at least four years of follow-up achieved complete or partial remission, and their kidney function improved over time.
- Rituximab was effective even when previous treatments with steroids and other immunosuppressive drugs had failed.
- Patients tolerated rituximab well and experienced no treatment-related serious side effects throughout the entire study.

"Rituximab may lead to major progress in the treatment of patients with idiopathic membranous nephropathy, and in consideration of its excellent safety profile, it might replace other toxic regimens as first line treatment of this disease," said Dr. Remuzzi.

An added benefit of rituximab is that it can be administered in one single intravenous infusion on an outpatient basis, while courses of steroids and other drugs for IMN require at least six months of continued treatment and often cause patients to become hospitalized due to complications.

Study co-authors include Paolo Cravedi, MD, PhD, Antonietta Chianca, PhD, Annalisa Perna, StatSciD, Barbara Ruggiero, MD, Flavio Gaspari, PhD, Alessandro Rambaldi, MD, and Maddalena Marasà, MD.

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

Most Popular News on Medindia

P
M
View All >>
X

Ask an Expert

Ask an Expert+
s
Government Launches Anti-ragging Website
 Government Launches Anti-ragging Website
S  Using Viagra For Fun Could Lead to Erectile Dysfunction in Young Men
Using Viagra For Fun Could Lead to Erectile Dysfu...