Medindia

X

Human Papilloma Virus Leaves Its Mark in Oropharyngeal Squamous Cell Carcinoma

by Bidita Debnath on  May 6, 2013 at 10:23 PM Research News   - G J E 4
A form of cancer that affects the cells lining the middle part of the throat, including the soft palate, the base of the tongue, the tonsils, and the pharynx is Oropharyngeal squamous cell carcinoma (OPSCC).
 Human Papilloma Virus Leaves Its Mark in Oropharyngeal Squamous Cell Carcinoma
Human Papilloma Virus Leaves Its Mark in Oropharyngeal Squamous Cell Carcinoma
Advertisement

High-risk types of human papilloma virus (HPV) are increasingly detected in patients with OPSCC; however, HPV-positive OPSCC is highly curable and patients with HPV have better survival compared to HPV-negative patients, whose cancers are usually associate with alcohol and tobacco use. To understand the molecular mechanisms underlying these differences, Jochen Hess and colleagues at University Hospital Heidelberg in Heidelberg, Germany monitored changes in DNA modifications in HPV-positive and HPV-negative OPSCCs.

Advertisement
In this issue of the Journal of Clinical Investigation, they identified a specific pattern of DNA modification that is dependent on the presence of HPV. This DNA modification pattern was significantly correlated with improved survival in three separate groups of OPSCC patients. This study identifies a specific cellular alteration that can predict clinical outcomes for patients with OPSCC.

Source: Eurekalert
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All